What is the correct drug, route, and dose for immediate management of this patient?
Pharmacology questions in the ADC written exam test applied prescribing decisions, not rote recall of drug names. This exam-level vignette tests your ability to work through clinical details and arrive at the correct management.
Ms. Priya Sharma, a 25-year-old woman with no significant medical history, is undergoing extraction of tooth 38 under inferior alveolar nerve block with 2% lidocaine with adrenaline 1:80,000. Five minutes after the injection, she develops tongue swelling, difficulty breathing, a hoarse voice, and feels dizzy. Her blood pressure drops to 80/50 mmHg and she appears pale and distressed. What is the correct drug, route, and dose for immediate management of this patient?
- A. Oral antihistamine (cetirizine) and observe for 30 minutes
- B. Hydrocortisone 200 mg IV to treat the allergic reaction
- C. Adrenaline 500 micrograms IM via autoinjector into the anterolateral thigh, repeated every 5 minutes if needed
- D. Adrenaline 500 micrograms intravenously, repeated every 5 minutes
- E. Adrenaline 300 micrograms IM into the deltoid muscle
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Show the answer and cited explanation
According to TG, for anaphylaxis: give adrenaline IM via autoinjector into the anterolateral thigh. The dose for adults/children >50 kg is 500 micrograms; for 20-50 kg is 300 micrograms; for 7.5-20 kg is 150 micrograms. Repeat every 5 minutes if needed. TG states preloaded autoinjectors are preferred over ampoules, and sufficient quantity for at least 2 doses should be available.
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