his severe penicillin allergy with anaphylaxis, what…
Pharmacology questions in the ADC written exam test applied prescribing decisions, not rote recall of drug names. This exam-level vignette tests your ability to work through clinical details and arrive at the correct management.
Rajesh Kumar, a 69-year-old man with prosthetic aortic valve, type 2 diabetes, and chronic kidney disease, presents to his dentist for extraction of an infected molar. He reports a severe penicillin allergy with previous anaphylaxis to amoxicillin 5 years ago. He takes metformin, lisinopril, and warfarin. His cardiologist has confirmed the need for endocarditis prophylaxis. The dentist is planning the antibiotic regimen and considering surgical antibiotic prophylaxis as well. Given his severe penicillin allergy with anaphylaxis, what is the most appropriate endocarditis prophylaxis regimen?
- A. Cephalexin 2g orally 60 minutes before procedure
- B. Doxycycline 100mg orally 60 minutes before procedure
- C. Amoxicillin 2g orally since he's on warfarin
- D. No antibiotics needed due to allergy severity
- E. Clindamycin 600mg intravenously within 120 minutes
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Show the answer and cited explanation
According to TG, for patients with severe hypersensitivity to penicillin, doxycycline 100mg orally 60 minutes before procedure is appropriate for endocarditis prophylaxis.
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